Research project title

Development of HA-peptide derivatives and coating optimization

Education level

Master (research-based)

Director/co-director

Director: Marc Lavertu

End of display

June 30, 2026

Areas of expertise

Biomedical engineering

Materials science and technology

Unit(s) and department(s)

Department of Chemical Engineering

Conditions

Send your application to anik.chevrier@polymtl.ca

Detailed description

This project aims to develop an advanced nanoparticle platform for mRNA delivery, based on a chitosan-mRNA core coated with a hyaluronic acid (HA) coating functionalized with neurotargeting peptides. The student will focus on the design and optimization of hyaluronic acid derivatives functionalized with neurotargeting peptides, as well as their use for coating the nanoparticles. They will work on the coupling conditions (EDC/NHS), the functionalization density, and study the impact of the coating on colloidal properties and neuronal uptake, leveraging Stunner AF, DLS, AF4, and NTA assays.

Financing possibility

Project funded by a research contract