Research project title
Development and optimization of chitosan derivatives for the formulation of mRNA nanoparticle cores
Education level
Master (research-based)
Director/co-director
Director: Marc Lavertu
End of display
June 30, 2026
Areas of expertise
Materials science and technology
Unit(s) and department(s)
Department of Chemical Engineering
Conditions
Send your application to anik.chevrier@polymtl.ca
Detailed description
This project aims to develop an advanced nanoparticle platform for mRNA delivery, based on a chitosan-mRNA core coated with a hyaluronic acid (HA) coating functionalized with neurotargeting peptides. The student will work on the development and optimization of chitosan derivatives for the formulation of the mRNA nanoparticle cores. They will explore different chitosans (DDA/Mn, quaternized or PEGylated chitosans), optimize formulation conditions (N:P ratios, microfluidics, additives), and characterize the particles using a reference analytical panel (Stunner AF, DLS, AF4, etc.).
Financing possibility
Project funded by a research contract
Marc Lavertu
Associate Professor
