Research project title
Additives, freeze-drying, stability and concentration
Education level
Master (research-based)
Director/co-director
Director: Marc Lavertu
End of display
June 30, 2026
Areas of expertise
Materials science and technology
Unit(s) and department(s)
Department of Chemical Engineering
Conditions
Send your application to anik.chevrier@polymtl.ca
Detailed description
This project aims to develop an advanced nanoparticle platform for mRNA delivery, based on a chitosan-mRNA core coated with a hyaluronic acid (HA) coating functionalized with neurotargeting peptides. The student will investigate the effect of additives (histidine, trehalose, poloxamer) on the stability and robustness of the coated-HA nanoparticles, develop and optimize lyophilization cycles, conduct stability studies (real and accelerated), and implement Amicon ultrafiltration concentration methods as a first step towards total fat fusion (TFF). They will evaluate the physicochemical properties and in vitro efficacy of the formulations before and after lyophilization and concentration, using a standard analytical panel (Stunner AF, DLS, AF4, NTA, etc.).
Financing possibility
Project funded by a research contract
Marc Lavertu
Associate Professor
