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Nikola Stikov
B.S., M.S., Ph.D., Université Stanford

Phone: (514) 340-4711 Ext. 4549 Room: L-5608

Research interests and affiliations

Research interests
  • Magnetic Resonance Imaging (MRI)
  • In vivo histology
  • Biophysical modeling
  • Brain and heart microstructure
  • Multiple sclerosis

Our team has access to world-class imaging facilities at the University of Montreal, and we also work closely with collaborators at the Montreal Neurological Institute and the newly established Stanford Center for Cognitive and Neurobiological Imaging. Due to the interdisciplinary and international nature of our projects, we are open to students from a wide range of scientific backgrounds.

If you are interested in joining, please send e-mail with your CV to: nikola.stikov@polymtl.ca.

Below is a list of ongoing projects:

  • Characterizing the myelin microstructure in patients with multiple sclerosis (collaboration with the Montreal Neurological Institute)
  • Building software for simulating and fitting magnetic resonance data to tissue models (collaboration with the Stanford Center for Cognitive and Neurobiological Imaging)
  • Studying the sexual dimorphism in the myelin thickness (g-ratio) during normal brain development
  • Histological validation of the accuracy and precision of myelin imaging techniques
  • Pulse sequence development for magnetic resonance spectroscopy and diffusion in the heart and the brain

Publications

Recent publications
Conference paper
Mei, J., Tremblay, C., Stikov, N., Desrosiers, C. & Frasnelli, J. (2021). Differentiation of Parkinson's disease and non-Parkinsonian olfactory dysfunction with structural MRI data. Paper presented at the Medical Imaging 2021: Computer-Aided Diagnosis (8 pages). Retrieved from https://doi.org/10.1117/12.2581233
Journal article
Boudreau, M., Poline, J.-B., Bellec, P. & Stikov, N. (2021). On the open-source landscape of PLOS Computational Biology. PLOS Computational Biology, 17(2), 28 pages. Retrieved from https://doi.org/10.1371/journal.pcbi.1008725
Conference paper
Tagge, I.J., Leppert, I.R., Fetco, D., Campbell, J.S., Rudko, D.A., Stikov, N., Pike, G.B., Giacomini, P.S., Arnold, D.L. & Narayanan, S. (2021). Reduced Myelin Content Preceding Acute White Matter Lesions is Associated with Permanent Tissue Loss [Poster]. Paper presented at the ACTRIMS Forum 2021. (Published in Multiple Sclerosis Journal, 27(1 (Suppl.))).
Journal article
Boshkovski, T., Cohen-Adad, J., Misic, B., Arnulf, I., Corvol, J.-C., Vidailhet, M., Lehéricy, S., Stikov, N. & Mancini, M. (2021). The Myelin-Weighted Connectome in Parkinson's Disease. Movement Disorders, 12 pages. Retrieved from https://doi.org/10.1002/mds.28891

Biography

Co-director, Neuroimaging Research Laboratory (NeuroPoly) http://www.polymtl.ca/recherche/rc/unites/details.php?NoUnite=184

Researcher at Montreal Heart Institute https://www.icm-mhi.org/en/contact-us/employees?letter=S

 

Dr. Nikola Stikov is assistant professor of Biomedical Engineering, a researcher at the Montreal Heart Institute, and co-director of NeuroPoly, the Neuroimaging Research Laboratory at École Polytechnique. His research spans the gamut of quantitative magnetic resonance imaging, from basic issues of standardization and accuracy, to biophysical modeling, microstructural imaging and clinical applications. His group is particularly interested in developing and validating novel biomarkers for non-invasive characterization of the brain and heart microstructure during development, disease and treatment, thus pushing the boundaries of the emerging field of in vivo histology.

Prior to joining the Polytechnique faculty, Dr. Stikov completed his postdoctoral training with Dr. Bruce Pike at the Montreal Neurological Institute, and his Ph.D. degree with Dr. John Pauly and Dr. Dwight Nishimura at Stanford University. For his accomplishments, Dr. Stikov has been awarded the Stanford Electrical Engineering Outstanding Service Award in 2003, and the Stanford University Centennial Teaching Assistant Award in 2007. He is also the founder of MRBalkan.org, and has organized several international conferences for magnetic resonance imaging under the auspices of the International Society for Magnetic Resonance in Medicine (ISMRM). In 2014, Dr. Stikov was elected Junior Fellow of the ISMRM.

 

Distinctions

  • Junior Fellow of the International Society for Magnetic Resonance in Medicine (2014) 
  • Montreal Neurological Institute CECR Fellowship (2010)
  • Stanford Centennial Teaching Assistant Award (2007)
  • Stanford Electrical Engineering Outstanding Service Award (2003) 

Teaching

GBM2330 Principles of biomedical instrumentation https://moodle.polymtl.ca/enrol/index.php?id=879

ELE6812 Image processing and analysis https://moodle.polymtl.ca/course/view.php?id=31

GBM6330 Biomedical Emergent Technologies https://moodle.polymtl.ca/enrol/index.php?id=1720

 

Supervision at Polytechnique

COMPLETED

  • Ph.D. Thesis (1)

    • Boshkovski, T. (2021). The Myelin-Weighted Connectome: A Multiplex Approach to Characterize Brain Function and Structure (Ph.D. Thesis, Polytechnique Montréal). Retrieved from https://publications.polymtl.ca/6324/
  • Master's Thesis (3)

    • Nami, H. (2019). Clustering of the White Matter Tracts in the Rat Spinal Cord Based on Quantitative Histology (Master's Thesis, Polytechnique Montréal). Retrieved from https://publications.polymtl.ca/4009/
    • Saliani, A. (2017). Construction d'un atlas de la microstructure de la matière blanche de la moelle épinière chez le rat à partir d'acquisitions histologiques (Master's Thesis, École Polytechnique de Montréal). Retrieved from https://publications.polymtl.ca/2734/
    • Vuong, M.T. (2017). Comparison of Myelin Imaging Techniques in Ex Vivo Spinal Cord (Master's Thesis, École Polytechnique de Montréal). Retrieved from https://publications.polymtl.ca/2683/

Press review about Nikola Stikov

September 21, 2021, Organization for Human Brain Mapping, NEUROSALIENCE S2 Ep3: Nikola Stikov, Physicist, Engineer, Open Scientist & Communicator Dans cet épisode du balado « Neurosalience » produit par la société savante Organisation For Human Brain Mapping, Nikola Stikov, professeur agrégé au Département de génie électrique de Polytechnique Montréal, discute à propos de ses recherches sur l'utilisation de l'imagerie à résonance magnétique pour obtenir des informations sur la structure cellulaire du cerveau (en anglais).