TransMedTech Institute

Microfluidics

Mission

At the interface between microfluidics and clinical oncology, we design lab-on-a-chip labs for you to accelerate your research in instrumentation, imaging, drug discovery and for personalized analysis of the response to anti-cancer treatments.

Expertise

Benjamin Péant, Ph.D.
Expert in microfluidic technologies, cell/tissue imaging and confocal microscopy, chemotherapeutic treatments and tissue microdissection.

Amélie St-Georges-Robillard, PhD. 
She develops hyperspectral imaging techniques for microfluidic chip analysis of the response to chemotherapy of multicellular tumor spheroids.

Jennifer Kendall-Dupont, M.Sc.
Specialist in biology, expert in microdissected tumor chip culture.

  • Design, characterization and operation of microfluidic chips in biological media
  • Microfabrication and 3D printing for silicone molding (PDMS)
  • 3D tumor cutting
  • Training students on equipment (including health and safety)
  • Histopathological analysis of tumor microarrays
  • Optical imaging and linkage with the CRCHUM imaging platform
  • Development of algorithms for image analysis and analysis of results

Services

Personalized analysis of the response to anti-cancer treatments by laboratories on chips.

  1. Modeling, designing and manufacturing of microfluidic chips for 3D culture and precise control of the cellular microenvironment
  2. Production of micro-dissected tumors and on-chip spheroids formation for drug discovery and characterization
  3. Precise fabrication and molding of silicone materials (PDMS) (vascular ghosts, optics, etc.) according to your needs
  4. Imaging and analysis of fluorescence images
  5. Training and technical support for any student / researcher wishing to develop and / or use the aforementioned techniques
  6. Development of research projects and support for writing background applications integrating microfluidic components and ex vivo culture of 3D cell models

Our well-established team is able to receive tumor samples from the clinic and treat them in a systematic and repeatable way over long periods of time (the response to treatment being typically evaluated over 9-12 months).

    EQUIPMENT

    • Microdissection equipment
    • Tools for mold design and production for microfluidic chip fabrication
    • Culture rooms
    • Molecular pathology platform of CRCHUM
    • CRCHUM microscopy platform
    • Animal Platform of CRCHUM

    LEAD CO-researcherS

    Thomas Gervais, Ph.D.
    Full Professor, Department of Engineering Physics, Polytechnique Montréal; Associate Researcher CRCHUM and Montreal Cancer Institute

    Anne-Marie Mes-Masson, Ph.D.
    Full Professor, Université de Montréal and Regular Researcher CRCHUM and Montreal Cancer Institute

    ACCESS

    Operating expenses are shared between users and central facilities in a non-profit approach.

    These services are offered to our employees in a perspective of development of academic collaborations and dissemination of the approaches we develop. For industry, we offer chip manufacturing, ex vivo tissue manipulation, and results analysis in the form of industrial contracts.

    Contactez microfluidique.cr.chum@ssss.gouv.qc.ca