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Philippe Pouliot
Ph.D. (Rutgers)

Phone: (514) 340-4711 Ext. 2306 Fax: (514) 340-4078 Room: L-5606; phone (ICM-MHI: 514-376-3330 x 2769 ou/or x 3743; bureau/office S.3330)

Research interests and affiliations

Research interests

My current research interests focus mostly on biomedical imaging of the brain and of the heart, and on advanced data analysis methods. I am currently aiming to build expertise in magnetic resonance imaging. This involves a number of projects requiring sequence development, with applications in atherosclerosis, stroke, pediatrics, aging, exercise and epilepsy. This work is mainly based at the Montreal Heart Institute. I am also directing research projects in multimodal imaging of animal and human epilepsy, which contribute to a better understanding of the neuro-metabolic-vascular coupling. These experiments call for a broad range of measurements, requiring diverse expertise: electrophysiology (electroencephalography, extracellular electrodes), near infrared spectroscopy, intrinsic optical imaging, optical coherence tomography, two-photon, and magnetic resonance.

Expertise type(s) (NSERC subjects)
  • 2957 Mathematical biology and physiology
  • 2958 Mathematical physics
  • 2960 Mathematical modelling
  • 3100 PHYSICS
  • 3104 Particle physics
  • 3153 Classical and quantum physics
  • 3154 Relativity and gravitation


Recent publications
Journal article
de Montgolfier, O., Pincon, A., Pouliot, P., Gillis, M.-A., Bishop, J., Sled, J.G., Villeneuve, L., Ferland, G., Levy, B.I., Lesage, F., Thorin-Trescases, N. & Thorin, E. (2019). High systolic blood pressure induces cerebral microvascular endothelial dysfunction, neurovascular unit damage, and cognitive decline in mice. Hypertension, 73(1), 217-228. Retrieved from
Journal article
Rautureau, Y., Deschambault, V., Higgins, M.-È., Rivas, D., Mecteau, M., Geoffroy, P., Miquel, G., Uy, K., Sanchez, R., Lavoie, V., Brand, G., Nault, A., Williams, P.-M., Suarez, M.L., Merlet, N., Lapointe, L., Duquette, N., Gillis, M.-A., Samami, S., Mayer, G., Pouliot, P., Raignault, A., Maafi, F., Brodeur, M.R., Levesque, S., Guertin, M.-C., Dubé, M.-P., Thorin, É., Rhainds, D., Rheaume, É. & Tardif, J.-C. (2018). Adenylate cyclase type 9 (ADCY9) inactivation protects from atherosclerosis only in the absence of cholesteryl ester transfer protein (CETP). Circulation, 138(16), 1677-1692. Retrieved from
Journal article
Damseh, R., Pouliot, P., Gagnon, L., Sakadzic, S., Boas, D., Cheriet, F. & Lesage, F. (2018). Automatic Graph-based Modeling of Brain Microvessels Captured with Two-Photon Microscopy. IEEE Journal of Biomedical and Health Informatics. Retrieved from
Journal article
Castonguay, A., Lefebvre, J., Pouliot, P. & Lesage, F. (2018). Comparing three-dimensional serial optical coherence tomography histology to MRI imaging in the entire mouse brain. Journal of Biomedical Optics, 23(1), 9 pages. Retrieved from


Philippe holds a Ph.D. in physics from Rutgers University and was a researcher in theoretical particle physics at UC Santa Barbara, UT Austin and Imperial College London. He was also an associate at Morgan Stanley in London, specialized in asset-liability management. He has been a researcher in biomedical engineering at Ecole Polytechnique Montreal and at the Montreal Heart Institute since 2010. Publications in Biomedical Engineering

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52 S. Fraser, O. Dupuy, P. Pouliot, F. Lesage, L. Bherer, Comparable Cerebral Oxygenation Patterns in Younger and Older Adults during Dual-Task Walking with Increasing Load, Front Aging Neurosci. 2016 Oct 20;8:240.

51 L. Gagnon, S. Sakadžić, F. Lesage, P. Pouliot, A.M. Dale, A. Devor, R.B. Buxton, D.A. Boas, Validation and optimization of hypercapnic-calibrated fMRI from oxygen-sensitive two-photon Microscopy, Phil. Trans. B 2016, 20150359.

50 T. Lam, P.K. Avti, P. Pouliot, J.-C. Tardif, É. Rhéaume, Frédéric Lesage, A.K. Kakkar, Magnetic Resonance Imaging/Fluorescence Dual Modality Protocol Using Designed Phosphonate Ligands Coupled to Superparamagnetic Iron Oxide Nanoparticles, J. Mater. Chem. B 2016, 4, 3969-3981.

49. T. Lam, P.K. Avti, P. Pouliot, J.-C. Tardif, É. Rhéaume, Frédéric Lesage, A.K. Kakkar, Fabricating water dispersible superparamagnetic iron oxide nanoparticles for biomedical applications through ligand exchange and direct conjugation, Nanomaterials 2016, 6(6), 100.

 48. D. Safi, R. Béland, D.K. Nguyen, P. Pouliot, I. Mohamed, P. Vannasing, J. Tremblay, M. Lassonde, A. Gallagher, Recruitment of the left pre-central gyrus during lexical and phonological reading in a patient with reading epilepsy: a combined MEG-EEG, fNIRS-EEG and fMRI-EEG study, Epilepsy and Behavior Case Reports 2016.

47. Y. Zerouali, P. Pouliot, M. Robert, I. Mohamed, A. Bouthillier, F. Lesage, D.K. Nguyen, Magnetoencephalographic signatures of insular epileptic spikes based on functional connectivity, Human Brain Mapping 2016. 46. S. Mekari, S. Fraser, L. Bosquet, C. Bonnéry, V. Labelle, P. Pouliot, F. Lesage, L. Bherer, The relationship between exercise intensity, cerebral oxygenation and cognitive performance in young adults, European Journal of Applied Physiology 2015,115:2189-97. 45. K. Peng, P. Pouliot, F. Lesage, D.K. Nguyen, Multi-channel continuous EEG-fNIRS recording of focal seizures and interictal epileptiform discharges in human epilepsy: a review, Neurophotonics 2015. 44. K. Peng, D.K. Nguyen, P. Vannasing, J. Tremblay, F. Lesage, P. Pouliot, Using patient-specific hemodynamic response function in epileptic spike analysis of human epilepsy: a study based on EEG-fNIRS, NeuroImage, 2015;126:239-255. 43. C. Zhang, T.V. Esipova, S.A. Vinogradov, S. Bélanger, P. Pouliot, F. Lesage, Measurement of local partial pressure of oxygen in normoxia and epilepsy with phosphorescence lifetime microscopy, PLoS One. 2015,10:e0135536. 42. O. Dupuy, C. Gauthier, S.A. Fraser, L. Desjardins-Crépeau, M. Desjardins, S. Mekary, F. Lesage, R. Hoge, P. Pouliot, L. Bherer, Effect of physical fitness on executive function and related prefrontal cortex oxygenation in younger and older women, Frontiers in Human Neuroscience, 2015, 9:66. 41. A. Sabouni , P. Pouliot, A. Shmuel, F. Lesage, BRAIN Initiative: Fast and Parallel Solver for Real-Time Monitoring of the Eddy Current in the Brain for TMS Applications, Conf Proc IEEE Eng Med Biol Soc. 2014, 6250-3 40. B. Li, F. Maafi, R. Berti, P. Pouliot,E. Rhéaume, J.-C. Tardif, F. Lesage, Hybrid FMT-MRI applied to in vivo atherosclerosis imaging, Biomedical Optics Express 2014 Apr 28;5(5):1664-76. 39. M. Desjardins, R. Berti, P. Pouliot, S. Dubeau, F. Lesage, Multimodal study of the hemodynamic response to hypercapnia in anesthetized aged rats, Neurosci Lett. 2014 Mar 20;563:33-7. 38. M. Amiri, P. Pouliot, C. Bonnery, P.O. Leclerc, M. Desjardins, F. Lesage, Y. Joanette, fNIRS exploration of the hemodynamic changes allowing for the semantic processing of words in normal aging, Frontiers Neurology 2014 Dec 1;5:249. 37. M. Desjardins, P. Pouliot, V. Perlbarg, L. Desjardins-Crépeau, C. Gauthier, P.O. Leclerc, R. Hoge, L. Bherer, H. Benali, F. Lesage, Association of cardiovascular fitness with cognition, cerebral blood flow and oxygenation in aging, submitted to NeuroImage. 36. P.Pouliot, T.P.Y. Tran, V. Birca, P. Vannasing, J. Tremblay, M. Lassonde, D.K. Nguyen, Hemodynamic changes during posterior epilepsies: an EEG-fNIRS study, Epilepsy Research 2014 Jul;108(5):883-90. 35. K. Peng, D.K. Nguyen, P. Pouliot, Multi-channel continuous EEG-fNIRS recording of focal seizures and IEDs: a review of principles, methods, and applications, invited, book entitled: Infrared Spectroscopy: Theory, Developments and Applications, Nova (2013). 34. S. Belanger, B. Olivera, C. Casanova, P. Pouliot, F. Lesage, Neurovascular coupling in the deep brain using confocal fiber-optic endomicroscopy, invited, book entitled: Neuromethods, Springer Protocols (2013). 33. K. Peng, D.K. Nguyen,T. Tayah, P. Vannasing, J. Tremblay, M. Sawan, M. Lassonde, F. Lesage, P. Pouliot, fNIRS-EEG study of focal interictal discharges, Epilepsy Res. 2014 Mar;108(3):491-505. 32. J. LeLan, O. Dupuy,A. Kassab,M. Dehbozorgi, P. Pouliot, P. Vannasing,D.K. Nguyen, S.A. Fraser, L. Bherer, M. Lassonde,F. Lesage, M. Sawan, High-Channel-Count Wearable NIRS-EEG System for Long-Term Clinical Imaging, submitted to Journal of Biomedical Optics. 31. E. Guevara, P. Pouliot, D.K. Nguyen, F. Lesage, Optical imaging of acute epileptic networks in mice, Journal of Biomedical Optics, 18 (2013) 76021. 30. T. Lam, P. Avti, P. Pouliot, F. Lesage, A. Kakkar, Superparamagnetic Iron Oxide Based Nanoprobes for Imaging and Theranostics, submitted to Advances in Colloid and Interface Science, Epub 23891347. 29. J. El Helou, E. Bélanger-Nelson, M. Freyburger, S. Dorsaz, T. Curie, F. La Spada, P.-O. Gaudreault, E. Beaumont, P. Pouliot, F. Lesage, M. G. Frank, P. Franken, V. Mongrain, Neuroligin-1: a Link between Neuronal Activity and Sleep/Wake Regulation, PNAS 24 (2013) 9974-9. 28. D.K. Nguyen, J. Tremblay, P. Pouliot, P. Vannasing, O. Florea, L. Carmant, F. Lepore, M. Sawan,  F. Lesage, and M. Lassonde, Continuous near-infrared spectroscopy imaging of frontal  lobe seizures, Epilepsia, (2012). 27. P. Pouliot, V. T. Truong, C. Zhang, S. Dubeau, F. Lesage, Tight neurovascular coupling in a rat model of quasi-periodic interictal spiking using multispectral optical imaging, Proceedings of SPIE Photonics North, Montreal, Jun 6-8 (2012). 26. F. Lesage, C. Bonnery, P. Pouliot, Diffuse optical tomography and biophysical modeling of the aging brain, Proceedings of the 4th International Conference on the development of biomedical engineering, Ho Chi Minh City, Vietnam, Jan 8-12 (2012). 25. C. Bonnery, P.O. Leclerc, M. Desjardins, L. Bherer, R. Hoge, P. Pouliot, F. Lesage, Changes in diffusion path length with old age in diffuse optical tomography, to appear in J. Biomedical Optics 24. P. Pouliot, J. Tremblay, M. Robert, P. Vannasing, F. Lepore, M. Lassonde, M. Sawan, D.K. Nguyen and F. Lesage, Nonlinear hemodynamic responses in human epilepsy: a multimodal analysis with fNIRS-EEG and fMRI-EEG, Journal of Neuroscience Methods (2012), 204, 326-40. 23. D.K. Nguyen, J. Tremblay, P. Pouliot, P. Vannasing, O. Florea, L. Carmant, F. Lepore, M. Sawan,  F. Lesage, and M. Lassonde, Continuous near-infrared spectroscopy imaging of temporal lobe seizures, Epilepsy Research (2011), Epub Nov 17. 22. J S. Dubeau, M. Havlicek, E. Beaumont, G. Ferland, F. Lesage and P. Pouliot, Neurovascular deconvolution of optical signals as a proxy for the true neuronal inputs, submitted to Journal of Neuroscience Methods (2011). 25. M. Desjardins, P. Pouliot and F. Lesage, Principles and applications of diffuse optical imaging for the brain, to be published in Current Medical Imaging Reviews (2012). 20. E. Lareau, M. Sawan. F. Lesage, P. Pouliot and D.K. Nguyen, Multichannel wearable system dedicated for simultaneous electroencephalography/near infrared spectroscopy real-time data acquisitions, Journal of Biomedical Optics (2011). 19. S. Dubeau, M. Desjardins, P. Pouliot, E. Beaumont, P. Gaudreau, G. Ferland and F. Lesage, Biophysical model estimation of vascular parameters in a model of healthy aging, NeuroImage 57 (2011), 1480-91.

Publications in Theoretical Physics 18. P. Pouliot, Finite number of states, de Sitter space and quantum groups at roots of unity, Class. Quant. Grav. 21 (2004) 145-162. 17. P. Pouliot, Spectroscopy of gauge theories based on exceptional Lie groups, J. Phys. A34 (2001), 8631-8658. 16. P. Pouliot, Quantum determinism for free vector bosons in three dimensions, JHEP 0111 (2001) 028. 15. W. Fischler, E. Gorbatov, A. Kashani-Poor, R. McNees, S. Paban and P. Pouliot, The interplay between theta and T, JHEP 0006 (2000) 032. 14. W. Fischler, J. Gomis, E. Gorbatov, A. Kashani-Poor, S. Paban and P. Pouliot, Evidence for winding states in noncommutative quantum field theory, JHEP 0005 (2000) 024. 13. P. Pouliot, Molien function for duality, JHEP 9901 (1999) 021. 12. J. Polchinski and P. Pouliot, Membrane scattering with M-momentum transfer, Phys. Rev. D56 (1997)             6601-6606. 11. M. Douglas, D. Kabat, P. Pouliot and S. Shenker, D-branes and short distances in string theory, Nucl. Phys. B485 (1997) 85-127. 10. D. Kabat and P. Pouliot, A comment on zero-brane quantum mechanics, Phys. Rev. Lett. 77 (1996) 1004-1007. 9. P. Pouliot and M. Strassler, Duality and dynamical supersymmetry breaking in Spin(10), Phys. Lett. 373 B.             (1996) 40-43. 8. P. Pouliot and M. Strassler, A chiral SU(N) gauge theory and its non-chiral Spin(8) dual, Phys. Lett. 370 B             (1996) 76-82. 7. P. Pouliot, Duality in SUSY SU(N) with an antisymmetric tensor, Phys. Lett. 367 B (1996) 151-156. 6. P. Pouliot, Chiral duals of non-chiral SUSY gauge theories, Phys. Lett. 359 B (1995) 108-113. 5. K. Intriligator and P. Pouliot, Exact superpotentials, quantum vacua and duality in supersymmetric Sp(Nc) gauge theories, Phys. Lett. 353 B (1995) 471-476. 4. D. Finnell and P. Pouliot, Instanton calculations versus exact results in four-dimensional SUSY gauge theories, Nucl. Phys. B 453 (1995) 225-239. 3. P. Pouliot and N. Seiberg, (S)quark masses and nonabelian horizontal symmetries, Phys. Lett. 318 B (1993) 169-173. 2. R. P. Langlands, P. Pouliot and Y. Saint-Aubin, Conformal invariance in two-dimensional percolation, Bull. Am. Math. Soc. 30 (1994) 1-61. 1. R. P. Langlands, C. Pichet, P. Pouliot and Y. Saint-Aubin, On the universality of crossing probabilities in two-dimensional percolation, J. Stat. Phys. 67 (1992) 553-574.

Supervision at Polytechnique


  • Ph.D. Thesis (1)

    • Peng, K. (2016). Study of the Hemodynamic Response to Interictal Epileptiform Discharges in Human Epilepsy Using Functional Near Infrared Spectroscopy (Ph.D. Thesis, École Polytechnique de Montréal). Retrieved from
  • Master's Thesis (4)

    • De Almeida Gomes Akakpo, L.-K. (2016). Automatisation et optimisation de l'analyse de données de résonance magnétique pour les cerveaux de rongeur en développement (Master's Thesis, École Polytechnique de Montréal). Retrieved from
    • Arfaoui, N. (2014). Suppression des artefacts de mouvement dans les signaux de spectroscopie proche-infrarouge acquis pendant la marche (Master's Thesis, École Polytechnique de Montréal). Retrieved from
    • Dehbozorgi, M. (2014). Robust Pre-Clinical Software System for Real Time NIRS and EEG Monitoring (Master's Thesis, École Polytechnique de Montréal). Retrieved from
    • Bonnéry, C. (2012). Élaboration d'un outil logiciel d'analyse des données de spectroscopie proche infrarouge pour l'étude du vieillissement cognitif (Master's Thesis, École Polytechnique de Montréal). Retrieved from