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Philippe Pouliot
Ph.D. (Rutgers)

Tél. : (514) 340-4711 poste 2306 Téléc. : (514) 340-4078 Local : L-5606
ph.pouliot@gmail.com; phone (ICM-MHI: 514-376-3330 x 2769 ou/or x 3743; bureau/office S.3330)

Intérêts de recherche et affiliations

Intérêts de recherche

Mes sujets de recherches portent principalement sur l'imagerie biomédicale du cerveau et du coeur, et les méthodes avancées d'analyse de données.

Je vise présentement à développer une expertise en imagerie par résonance magnétique. Ceci comprend une variété de projets demandant du développement de séquences, avec applications en athérosclérose, accidents cérébro-vasculaires, néonatalogie, le vieillissement, l'exercice et l'épilepsie. Ce travail a principalement lieu à l'Institut de Cardiologie de Montréal.

Je dirige aussi des projets de recherche en imagerie multimodale de l'épilepsie animale et humaine, qui contribuent à accroître notre compréhension du couplage neuro-métabolique-vasculaire. Ces expériences font appel à une grande variété de mesures, demandant des expertises diverses: électrophysiologie (électroencéphalographie, électrodes extracellulaires), imagerie par spectroscopie proche infrarouge, optique intrinsèque, tomographie par cohérence optique, deux-photons, et résonance magnétique.

Type(s) d'expertises (sujets CRSNG)
  • 1900 GÉNIE BIOMÉDICAL
  • 2900 MATHÉMATIQUES PURES
  • 2957 Mathématiques de la biologie et de la physiologie
  • 2958 Mathématiques de la physique
  • 2960 Modélisation mathématique
  • 3000 STATISTIQUE ET PROBABILITÉ
  • 3100 PHYSIQUE
  • 3104 Physique des particules
  • 3153 Physique classique et quantique
  • 3154 Relativité et gravitation

Publications

Publications récentes
Communication de conférence
Flores-Castro, A., Peng, K., Nguyen, D.K., Lesage, F., Pouliot, P., Rosas-Romero, R. & Guevara, E. (2017). Detecting epileptic seizures in advance using optical and electrical recordings. Communication présentée à 27th International Conference on Electronics, Communications and Computers (CONIELECOMP 2017), Puebla, Mexico (p. 4 pages). Tiré de https://doi.org/10.1109/CONIELECOMP.2017.7891811
Article de revue
Pouliot, P., Gagnon, L., Lam, T., Avti, P.K., Bowen, C., Desjardins, M., Kakkar, A.K., Thorin, E., Sakadzic, S., Boas, D.A. & Lesage, F. (2017). Magnetic resonance fingerprinting based on realistic vasculature in mice. Neuroimage, 149, 436-445. Tiré de https://doi.org/10.1016/j.neuroimage.2016.12.060
Article de revue
Lefebvre, J., Castonguay, A., Pouliot, P., Descoteaux, M. & Lesage, F. (2017). Whole mouse brain imaging using optical coherence tomography: reconstruction, normalization, segmentation, and comparison with diffusion MRI. Neurophotonics, 4(4). Tiré de https://doi.org/10.1117/1.NPh.4.4.041501
Article de revue
Fraser, S.A., Dupuy, O., Pouliot, P., Lesage, F. & Bherer, L. (2016). Comparable Cerebral Oxygenation Patterns in Younger and Older Adults during Dual-Task Walking with Increasing Load. Frontiers in Aging Neuroscience, 8, 9 pages. Tiré de https://doi.org/10.3389/fnagi.2016.00240

Biographie

Philippe a obtenu un doctorat de l'université Rutgers en physique et fut un chercheur en physique théorique des particules élémentaires à l'Université de la Californie à Santa Barbara, à l'Université du Texas à Austin et à Imperial College à Londres. Il fut aussi un banquier d'investissement pour Morgan Stanley à Londres, spécialiste de la gestion des actifs et passifs. Il est chercheur en génie biomédical à l'École Polytechnique de Montréal et à l'Institut de Cardiologie de Montréal depuis 2010.

Publications en Génie Biomédical

2016 P. Pouliot, L. Gagnon, T. Lam, P. Avti, M. Desjardins, A. Kakkar, E. Thorin, S. Sakadzic, D. Boas, F. Lesage, Magnetic resonance fingerprinting based on realistic vasculature in mice, NeuroImage.     

2016 S. Fraser, O. Dupuy, P. Pouliot, F. Lesage, L. Bherer, Comparable Cerebral Oxygenation Patterns in Younger and Older Adults during Dual-Task Walking with Increasing Load, Front Aging Neurosci. 2016 Oct 20;8:240.

2016 L. Gagnon, S. Sakadžić, F. Lesage, P. Pouliot, A.M. Dale, A. Devor, R.B. Buxton, D.A. Boas, Validation and optimization of hypercapnic-calibrated fMRI from oxygen-sensitive two-photon Microscopy, Phil. Trans. B 2016, 20150359.

2016 T. Lam, P.K. Avti, P. Pouliot, J.-C. Tardif, É. Rhéaume, Frédéric Lesage, A.K. Kakkar, Magnetic Resonance Imaging/Fluorescence Dual Modality Protocol Using Designed Phosphonate Ligands Coupled to Superparamagnetic Iron Oxide Nanoparticles, J. Mater. Chem. B 2016, 4, 3969-3981. 

2016 T. Lam, P.K. Avti, P. Pouliot, J.-C. Tardif, É. Rhéaume, Frédéric Lesage, A.K. Kakkar, Fabricating water dispersible superparamagnetic iron oxide nanoparticles for biomedical applications through ligand exchange and direct conjugation, Nanomaterials 2016, 6(6), 100.

2016 D. Safi, R. Béland, D.K. Nguyen, P. Pouliot, I. Mohamed, P. Vannasing, J. Tremblay, M. Lassonde, A. Gallagher, Recruitment of the left pre-central gyrus during lexical and phonological reading in a patient with reading epilepsy: a combined MEG-EEG, fNIRS-EEG and fMRI-EEG study, Epilepsy and Behavior Case Reports

2016 Y. Zerouali, P. Pouliot, M. Robert, I. Mohamed, A. Bouthillier, F. Lesage, D.K. Nguyen, Magnetoencephalographic signatures of insular epileptic spikes based on functional connectivity, Human Brain Mapping.

2015 S. Mekari, S. Fraser, L. Bosquet, C. Bonnéry, V. Labelle, P. Pouliot, F. Lesage, L. Bherer, The relationship between exercise intensity, cerebral oxygenation and cognitive performance in young adults, European Journal of Applied Physiology 2015, 115:2189-97.

2015 K. Peng, P. Pouliot, F. Lesage, D.K. Nguyen, Multi-channel continuous EEG-fNIRS recording of focal seizures and interictal epileptiform discharges in human epilepsy: a review, Neurophotonics 2015.

2015 K. Peng,D.K. Nguyen, P. Vannasing, J. Tremblay, F. Lesage, P. Pouliot, Using patient-specific hemodynamic response function in epileptic spike analysis of human epilepsy: a study based on EEG-fNIRS, NeuroImage, 2015;126:239-255.

2015 C. Zhang, T.V. Esipova, S.A. Vinogradov, S. Bélanger, P. Pouliot, F. Lesage, Measurement of local partial pressure of oxygen in normoxia and epilepsy with phosphorescence lifetime microscopy, PLoS One. 2015,10:e0135536

2015 O. Dupuy, C. Gauthier, S.A. Fraser, L. Desjardins-Crépeau, M. Desjardins, S. Mekary, F. Lesage, R. Hoge, P. Pouliot, L. Bherer, Effect of physical fitness on executive function and related prefrontal cortex oxygenation in younger and older women, Frontiers in Human Neuroscience, 2015, 9:66.

2014 A. Sabouni , P. Pouliot, A. Shmuel, F. Lesage, BRAIN Initiative: Fast and Parallel Solver for Real-Time Monitoring of the Eddy Current in the Brain for TMS Applications, Conf Proc IEEE Eng Med Biol Soc. 2014, 6250-3

2014 B. Li, F. Maafi, R. Berti, P. Pouliot,E. Rhéaume, J.-C. Tardif, F. Lesage, Hybrid FMT-MRI applied to in vivo atherosclerosis imaging, Biomedical Optics Express 2014 Apr 28;5(5):1664-76.

2014 M. Desjardins, R. Berti, P. Pouliot, S. Dubeau, F. Lesage, Multimodal study of the hemodynamic response to hypercapnia in anesthetized aged rats, Neurosci Lett. 2014 Mar 20;563:33-7.

2014 M. Amiri, P. Pouliot, C. Bonnery, P.O. Leclerc, M. Desjardins, F. Lesage, Y. Joanette, fNIRS exploration of the hemodynamic changes allowing for the semantic processing of words in normal aging, Frontiers Neurology 2014 Dec 1;5:249.

2014 M. Desjardins, P. Pouliot, V. Perlbarg, L. Desjardins-Crépeau, C. Gauthier, P.O. Leclerc, R. Hoge, L. Bherer, H. Benali, F. Lesage, Association of cardiovascular fitness with cognition, cerebral blood flow and oxygenation in aging, submitted to NeuroImage.

2013 P.Pouliot, T.P.Y. Tran, V. Birca, P. Vannasing, J. Tremblay, M. Lassonde, D.K. Nguyen, Hemodynamic changes during posterior epilepsies: an EEG-fNIRS study, Epilepsy Research 2014 Jul;108(5):883-90.

2013 K. Peng, D.K. Nguyen, P. Pouliot, Multi-channel continuous EEG-fNIRS recording of focal seizures and IEDs: a review of principles, methods, and applications, invited, book entitled: Infrared Spectroscopy: Theory, Developments and Applications, Nova (2013).

2013 S. Belanger, B. Olivera, C. Casanova, P. Pouliot, F. Lesage, Neurovascular coupling in the deep brain using confocal fiber-optic endomicroscopy, invited, book entitled: Neuromethods, Springer Protocols (2013).

2013 K. Peng, D.K. Nguyen,T. Tayah, P. Vannasing, J. Tremblay, M. Sawan, M. Lassonde, F. Lesage, P. Pouliot, fNIRS-EEG study of focal interictal discharges, Epilepsy Res. 2014 Mar;108(3):491-505.

2013 J. LeLan, O. Dupuy,A. Kassab,M. Dehbozorgi, P. Pouliot, P. Vannasing,D.K. Nguyen, S.A. Fraser, L. Bherer, M. Lassonde,F. Lesage, M. Sawan, High-Channel-Count Wearable NIRS-EEG System for Long-Term Clinical Imaging, submitted to Journal of Biomedical Optics.

2013 E. Guevara, P. Pouliot, D.K. Nguyen, F. Lesage, Optical imaging of acute epileptic networks in mice, Journal of Biomedical Optics, 18 (2013) 76021.

2013 T. Lam, P. Avti, P. Pouliot, F. Lesage, A. Kakkar, Superparamagnetic Iron Oxide Based Nanoprobes for Imaging and Theranostics, Advances in Colloid and Interface Science, Epub 23891347.

2013 J. El Helou, E. Bélanger-Nelson, M. Freyburger, S. Dorsaz, T. Curie, F. La Spada, P.-O. Gaudreault, E. Beaumont, P. Pouliot, F. Lesage, M. G. Frank, P. Franken, V. Mongrain, Neuroligin-1: a Link between Neuronal Activity and Sleep/Wake Regulation, PNAS 24 (2013) 9974-9.

2012 D.K. Nguyen, J. Tremblay, P. Pouliot, P. Vannasing, O. Florea, L. Carmant, F. Lepore, M. Sawan,  F. Lesage, and M. Lassonde, Continuous near-infrared spectroscopy imaging of frontal  lobe seizures, Epilepsia, (2012).

2012 C. Bonnery, P.O. Leclerc, M. Desjardins, L. Bherer, R. Hoge, P. Pouliot, F. Lesage, Changes in diffusion path length with old age in diffuse optical tomography, Journal of Biomedical Optics

2012 F. Lesage, C. Bonnery, P. Pouliot, Diffuse optical tomography and biophysical modeling of the aging brain, Proceedings of the 4th International Conference on the development of biomedical engineering, Ho Chi Minh City, Vietnam, Jan 8-12 2012.

2012 D.K. Nguyen, J. Tremblay, P. Pouliot, P. Vannasing, O. Florea, L. Carmant, F. Lepore, M. Sawan, et F. Lesage, M. Lassonde, Continuous near-infrared spectroscopy imaging of frontal lobe seizures, Epilepsia.

2012 P. Pouliot, V. T. Truong, C. Zhang, S. Dubeau, F. Lesage, Tight neurovascular coupling in a rat model of quasi-periodic interictal spiking using multispectral optical imaging, Proceedings of SPIE Photonics North, Montreal, Jun 6-8 (2012).

2012 F. Lesage, C. Bonnery, P. Pouliot, Diffuse optical tomography and biophysical modeling of the aging brain, Proceedings of the 4th International Conference on the development of biomedical engineering, Ho Chi Minh City, Vietnam, Jan 8-12 (2012).

2011 S. Dubeau, M. Desjardins, P. Pouliot, E. Beaumont, P. Gaudreau, G. Ferland et F. Lesage, Biophysical model estimation of vascular parameters in a model of healthy aging, NeuroImage 57(4), 1480-91

2011 M. Desjardins, P. Pouliot et F. Lesage, Principles and applications of diffuse optical imaging for the brain, à paraître dans Current Medical Imaging Reviews

2011 E. Lareau, M. Sawan. F. Lesage, P. Pouliot et D.K. Nguyen, Multichannel wearable system dedicatedfor simultaneous electroencephalography/near infrared spectroscopy real-time data acquisitions, Journal of Biomedical Optics, 16(9), 096014

2011 P. Pouliot, J. Tremblay, M. Robert, P. Vannasing, F. Lepore, M. Lassonde, M. Sawan, D.K. Nguyen et F.  Lesage, Nonlinear hemodynamic responses in human epilepsy: a multimodal analysis with fNIRS-EEG and fMRI-EEG, J Neurosci Methods, 204(2):326-340

2011 D.K. Nguyen, J. Tremblay, P. Pouliot, P. Vannasing, O. Florea, L. Carmant, F. Lepore, M. Sawan, et F. Lesage, M. Lassonde, Continuous near-infrared spectroscopy imaging of temporal lobe seizures, Journal of Epilepsy Research

2011 S. Dubeau, M. Havlicek, E. Beaumont, G. Ferland, F. Lesage et P. Pouliot, Neurovascular deconvolution of optical signals as a proxy for the true neuronal inputs, soumis à Journal of Neuroscience Methods

2011 F. Lesage, S. Dubeau, C. Zhang, E. Baraghis,G. Ferland, P. Gaudreau, et P. Pouliot, Intrinsic optical imaging and Doppler OCT assessment of changes in vascular reactivity with aging under caloric restriction, soumis à Biomedical Optics

2011 P. Pouliot, T. Truong Van, C. Zhang, S. Dubeau, D. K. Nguyen et F. Lesage, Biophysical model estimation in a rat model of epilepsy, soumis à Biomedical Optics

Publications en Physique Théorique

2003 P. Pouliot, Finite number of states, de Sitter space and quantum groups at roots of unity, Class. Quant. Grav. 21:145-162, 2004

2001 P. Pouliot, Spectroscopy of gauge theories based on exceptional Lie groups, J. Phys. A34 (2001), 8631-8658

2001 P. Pouliot, Quantum determinism for free vector bosons in three dimensions, JHEP 0111 (2001) 028

2000 W. Fischler, E. Gorbatov, A. Kashani-Poor, R. McNees, S. Paban et P. Pouliot, The interplay between theta and T, hep-th/0003216, JHEP 0006 (2000) 032

2000 W. Fischler, J. Gomis, E. Gorbatov, A. Kashani-Poor, S. Paban et P. Pouliot, Evidence for winding states   in noncommutative quantum field theory, JHEP 0005 (2000) 024

1998 P. Pouliot, Molien function for duality, JHEP 9901 (1999) 021

1997 J. Polchinski and P. Pouliot, Membrane scattering with M-momentum transfer, Phys. Rev. D56 (1997)           6601-6606

1996 P. Pouliot, Duality in supersymmetric gauge theories and other topics in supersymmetry, Ph.D. Thesis,        UMI-97-11113-mc (microfiche 1996)

1996 P. Pouliot, Chirality versus duality, in Perspectives of Strong Coupling Gauge Theories (SCGT 96), Nagoya, Japan, 286-290

1996 M. Douglas, D. Kabat, P. Pouliot et S. Shenker, D-branes and short distances in string theory, Nucl. Phys.B485 (1997) 85-127

1996 D. Kabat et P. Pouliot, A comment on zero-brane quantum mechanics, Phys. Rev. Lett. 77 (1996) 1004-1007

1996 P. Pouliot et M. Strassler, Duality and dynamical supersymmetry breaking in Spin(10), Phys. Lett. 373 B.     (1996) 40-43

1995 P. Pouliot et M. Strassler, A chiral SU(N) gauge theory and its non-chiral Spin(8) dual, Phys. Lett. 370 B       (1996) 76-82

1995 P. Pouliot, Duality in SUSY SU(N) with an antisymmetric tensor, Phys. Lett. 367 B (1996) 151-156

1995 P. Pouliot, Chiral duals of non-chiral SUSY gauge theories, Phys. Lett. 359 B (1995) 108-113

1995 K. Intriligator et P. Pouliot, Exact superpotentials, quantum vacua and duality in supersymmetric Sp(Nc)       gauge theories, Phys. Lett. 353 B (1995) 471-476

1995 D. Finnell et P. Pouliot, Instanton calculations versus exact results in four-dimensional SUSY gauge             theories, Nucl. Phys. B 453 (1995) 225-239

1993 P. Pouliot et N. Seiberg, (S)quark masses and nonabelian horizontal symmetries, Phys. Lett. 318  B (1993) 169-173

1992 R. P. Langlands, P. Pouliot et Y. Saint-Aubin, Conformal invariance in two-dimensional percolation, Bull. Am. Math. Soc. 30 (1994) 1-61

1992 R. P. Langlands, C. Pichet, P. Pouliot et Y. Saint-Aubin, On the universality of crossing probabilities in two-dimensional percolation, J. Stat. Phys. 67 (1992) 553-574

Encadrement à Polytechnique

TERMINÉ

  • Thèse de doctorat (1)

    • Peng, K. (2016). Study of the Hemodynamic Response to Interictal Epileptiform Discharges in Human Epilepsy Using Functional Near Infrared Spectroscopy (Thèse de doctorat, École Polytechnique de Montréal). Tiré de http://publications.polymtl.ca/2153/
  • Mémoire de maîtrise (3)

    • Arfaoui, N. (2014). Suppression des artefacts de mouvement dans les signaux de spectroscopie proche-infrarouge acquis pendant la marche (Mémoire de maîtrise, École Polytechnique de Montréal). Tiré de http://publications.polymtl.ca/1576
    • Dehbozorgi, M. (2014). Robust Pre-Clinical Software System for Real Time NIRS and EEG Monitoring (Mémoire de maîtrise, École Polytechnique de Montréal). Tiré de http://publications.polymtl.ca/1593
    • Bonnéry, C. (2012). Élaboration d'un outil logiciel d'analyse des données de spectroscopie proche infrarouge pour l'étude du vieillissement cognitif (Mémoire de maîtrise, École Polytechnique de Montréal). Tiré de http://publications.polymtl.ca/780