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Caroline Hoemann
Ph.D.

Phone: (514) 340-4711 Ext. 4848 Fax: (514) 340-4159 Room: A-677.1
(514) 340-4848
Areas of expertise
Biomedical engineering

Research interests and affiliations

Research interests

My tissue engineering research program is developing novel biomaterial implants that stimulate subchondral bone and articular cartilage repair. Our approach is to develop solid, thrombogenic implants that stimulate macrophages to release endogenous wound-healing factors on-site. By another approach, polymer formulations are being developed to inject in the joint after knee surgery, to suppress the type of global knee inflammation that works against new tissue growth. We are analyzing the role of exosomes, small thrombogenic lipid vesicles released by cells, on the inflammatory process. We are using a library of structurally distinct chitosans, and fluorescent chitosan derivatives to define molecular motifs that stimulate specific therapeutic inflammatory responses both in vitro and in vivo.Our long-term aim is to understand how inflammation guides tissue regeneration, and to bring new medical devices to the clinic that can be used to treat people suffering from arthritis.

Expertise type(s) (NSERC subjects)
  • 1900 BIOMEDICAL ENGINEERING

Publications

Recent publications
Journal article
Dwivedi, G., Chevrier, A., Hoemann, C.D. & Buschmann, M.D. (2017). Bone Marrow Progenitor Cells Isolated from Young Rabbit Trochlea Are More Numerous and Exhibit Greater Clonogenic, Chondrogenic, and Osteogenic Potential than Cells Isolated from Condyles. Cartilage. Retrieved from https://doi.org/10.1177/1947603517693044
Journal article
Li, X., Ghavidel Mehr, N., Guzman-Morales, J., Favis, B.D., De Crescenzo, G., Yakandawala, N. & Hoemann, C.D. (2017). Cationic osteogenic peptide P15-CSP coatings promote 3-D osteogenesis in poly(epsilon-caprolactone) scaffolds of distinct pore size. Journal of Biomedical Materials Research Part A, 105(8), 2171-2181. Retrieved from https://doi.org/10.1002/jbm.a.36082
Journal article
Hoemann, C.D., Marchand, C., Rivard, G.-E., El-Gabalawy, H. & Poubelle, P.E. (2017). Effect of chitosan and coagulation factors on the wound repair phenotype of bioengineered blood clots. International Journal of Biological Macromolecules. Retrieved from https://doi.org/10.1016/j.ijbiomac.2017.04.114
Journal article
Sim, S., Chevrier, A., Garon, M., Quenneville, E., Lavigne, P., Yaroshinsky, A., Hoemann, C.D. & Buschmann, M.D. (2017). Electromechanical probe and automated indentation maps are sensitive techniques in assessing early degenerated human articular cartilage. Journal of Orthopaedic Research, 35(4), 858-867. Retrieved from https://doi.org/10.1002/jor.23330

Teaching

GBM1620: Molecular and cellular biology for engineers

GBM3610 :  Molecular and cellular biology laboratory for engineers

GBM3620 : Immunity and biomolecular interactions

ELE3000: Individual project in biomedical engineering

GCH4391: Individual project in chemical engineering I/II

Supervision at Polytechnique

IN PROGRESS

  • Ph.D. (1)

    • Mathieu, Colleen. Étude du rôle des biomatériaux et des exosomes dans l'inflammation des articulations synoviales et la chondrogenèse pour le développement d'une thérapie.
  • Undergraduate (1)

    • Beland, Daniel. UPIR: use of ellagic acid in thrombogenesis assays.

COMPLETED

  • Ph.D. Thesis (5)

    • Ghavidel Mehr, N. (2014). Highly Structured and Surface Modified Poly (e-Caprolactone) Scaffolds Derived from Co-Continuous Polymer Blends for Bone Tissue Engineering (Ph.D. Thesis, École Polytechnique de Montréal). Retrieved from http://publications.polymtl.ca/1484
    • Amini, S. (2011). Stress Relaxation of Growth Plate Tissue under Uniform Compressive Load : Relationship Between Mechanical Response and Extracellular Matrix Bio-Composition and Structure (Ph.D. Thesis, École Polytechnique de Montréal). Retrieved from http://publications.polymtl.ca/726
    • Marchand, C. (2010). Étude de l'implant chitosane glycérol-phosphate/sang avec/sans facteurs de coagulation sur la réparation du cartilage articulaire et de l'os sous-chondral (Ph.D. Thesis, École Polytechnique de Montréal). Retrieved from http://publications.polymtl.ca/377
    • Tran-Khanh, N. (2007). Culture de chondrocytes en agarose : dépendance avec l'âge et caractérisation de la croissance en interface (Ph.D. Thesis, École Polytechnique de Montréal).
    • Chevrier, A. (2004). Application du chitosane pour la réparation de lésions du cartilage articulaire (Ph.D. Thesis, École Polytechnique de Montréal).
  • Master's Thesis (4)

    • Mathieu, C. (2012). Étude de l'angiogenèse et de la distribution des cellules souches mésenchymateuses dans des défauts ostéochondraux chez le lapin (Master's Thesis, École Polytechnique de Montréal). Retrieved from http://publications.polymtl.ca/1061
    • Lafantaisie-Favreau, C.-H. (2011). Évaluation des réponses cellulaires et tissulaires précoces induites par des implants sous-chondraux et présolidifiés composés de chitosane/sang dans un modèle ostéochondral (Master's Thesis, École Polytechnique de Montréal). Retrieved from http://publications.polymtl.ca/735
    • Chavane, N. (2007). Suivi en ligne de la production de protéines recombinantes en bioréacteur par résonance plasmonique de surface (Master's Thesis, École Polytechnique de Montréal).
    • Ma, O. (2006). Targeted derivatization of rhodamine B isothiocyanate-chitosan for the study of its interaction with cells (Master's Thesis, École Polytechnique de Montréal).

Press review about Caroline Hoemann

September 4, 2017, L'actualité, Actus santé : pour y voir clair Selon Caroline Hoemann, professeure titulaire au Département de génie chimique de Polytechnique Montréal, la carapace des crevettes pourrait venir au secours de nos articulations.
June 15, 2017, Ameq en ligne, Contre l'arthrose et les cartilages vieillissants, le chitosane, un sucre complexe qui peut réduire l'inflammation Mention de Caroline Hoemann, professeure titulaire au Département de génie chimique de Polytechnique Montréal et spécialiste en biomatériaux et en génie tissulaire.