DOMINO is the result of a unique collaboration between CI managers, the Direction of public safety of Montreal and the Centre risque & performance of Polytechnique Montréal. It is a decision support tool that aims at anticipating and modeling the spatial and temporal spread of domino effects between IE. The functioning of the tool rests on a consequences-based risk management approach, which aims to assess the impact of the failure of a CI without considering the causes that led to this failure. The results produced by DOMINO allow CI managers and responsible of public safety to put in place coherent prevention and protection measures allowing them to hedge against risks related to interdependencies.